Intravenous immunoglobulins - understanding properties and mechanisms

Three cases of systemic lupus erythematosus and review of the mechanisms concerning treatment with intravenous immunoglobulins (IVIG).

The systemic lupus erythematosus (SLE) is an autoimmune disorder with a broad array of clinical signs. In this research, we aimed to use intravenous immunoglobulins (IVIG) called intacglobin as monotherapy to manage an SLE in three patients. Laboratory investigations for SLE diagnosis were done, including the detection of anti-nuclear antibodies (ANA) and SLE confirmation by detecting high tite...

Intravenous immunoglobulins control scleromyxoedema.

BACKGROUND Scleromyxoedema is a variant of papular mucinosis affecting the skin and internal organs. The different therapeutic approaches proposed for scleromyxoedema are still unsatisfactory. Intravenous immunoglobulin (IVIg) has been successfully employed in the treatment of connective tissue diseases and vasculitides. PATIENTS The successful treatment of three cases of scleromyxoedema with...

Properties and mechanisms of immunoglobulins for congenital cytomegalovirus disease.

Immunoglobulins are one major component of adaptive immunity to external and resident microorganisms, evolving very early in phylogenesis. They help eukaryotes in controlling infections, mainly through their neutralizing activity, which quenches both the cytopathic and inflammatory potential of invading microorganisms. Cytomegalovirus (CMV)-related disease is generally blunted in seropositive s...

Autoimmune neuropathies and treatment with intravenous immunoglobulins

Clinical Application and Functional Mechanisms of Intravenous Immunoglobulin: an Overview

Previous, Intravenous Immunoglobulin (IVIG) has been used for treatment of patients with immunodeficiency. However, recent studies have shown that IVIG is a suitable approach for treatment of inflammatory and autoimmune diseases. Although the exact mechanism of IVIG action is not well known, recent findings have demonstrated that IVIG impacts on expression and function of FC receptors of immuno...